Gneyulins A and B, stilbene trimers, and noidesols A and B, dihydroflavonol-C-glucosides, from the bark of Gnetum gnemonoides

Yoko Shimokawa; Yusuke Akao; Yusuke Hirasawa; Khalijah Awang; A Hamid A Hadi; Seizo Sato; Chihiro Aoyama; Jiro Takeo; Motoo Shiro; Hiroshi Morita

doi:10.1021/np9007987

Gneyulins A and B, stilbene trimers, and noidesols A and B, dihydroflavonol-C-glucosides, from the bark of Gnetum gnemonoides

J Nat Prod. 2010 Apr 23;73(4):763-7. doi: 10.1021/np9007987.

Authors

Yoko Shimokawa¹, Yusuke Akao, Yusuke Hirasawa, Khalijah Awang, A Hamid A Hadi, Seizo Sato, Chihiro Aoyama, Jiro Takeo, Motoo Shiro, Hiroshi Morita

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.

PMID: 20192242
DOI: 10.1021/np9007987

Abstract

Gneyulins A (1) and B (2), two new stilbene trimers consisting of oxyresveratrol constituent units, and noidesols A (3) and B (4), two new dihydroflavonol-C-glucosides, were isolated from the bark of Gnetum gnemonoides. The structures and configurations of 1-4 were elucidated on the basis of 2D NMR correlations and X-ray analysis. Gneyulins A (1) and B (2) showed inhibition of Na(+)-glucose transporters (SGLT-1 and SGLT-2).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Crystallography, X-Ray
Flavonols / chemistry
Flavonols / isolation & purification*
Flavonols / pharmacology
Glucosides / chemistry
Glucosides / isolation & purification*
Glucosides / pharmacology
Gnetum / chemistry*
Malaysia
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry
Sodium-Glucose Transporter 1 / antagonists & inhibitors
Sodium-Glucose Transporter 2 Inhibitors
Stilbenes / chemistry
Stilbenes / isolation & purification*
Stilbenes / pharmacology

Substances

Flavonols
Glucosides
Sodium-Glucose Transporter 1
Sodium-Glucose Transporter 2 Inhibitors
Stilbenes
gneyulin A
gneyulin B
noidesol A
noidesol B